Is phrenic nerve motor responses an option to SVC in clinical trials for ALS?

Respiratory tests are fundamental for monitoring respiratory function in ALS, and essential in clinical trials. Slow vital capacity (SVC) was canceled in some countries to prevent COVID-19 transmission. This study aimed to test phrenic nerve motor responses as an option to SVC in clinical trials. It found that contrary to SVC, meanPhrenAmpl is non-volitional and not associated with aerosolization risk. https://www.tandfonline.com/doi/full/10.1080/21678421.2021.1895842?scroll=top&needAccess=true

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