Topline results from the Phase 2a trial of Tegoprubart have been announced, showing the drug to be well-tolerated, with no drug-related serious adverse events. This 12 week trial was an open label, dose escalating, safety, and biomarker study. The trial also demonstrated tegoprubart dose-dependent target engagement and pro-inflammatory biomarkers associated with ALS were dose-dependently reduced. Pro-inflammatory biomarker reduction was associated with a non-significant trend toward slowing disease progression as measured by ALSFRS-R. Click here to read the news release. More information about the trial is available here.
